Hep C Calculator

Global Cost-effectiveness Analysis of Hepatitis C Treatment


About Hepatitis C

An estimated 71 million people are living with hepatitis C virus (HCV). It is a major cause of cirrhosis, end-stage liver disease, and hepatocellular carcinoma. The elimination of HCV infection by 2030 is a stated objective made by the World Health Assembly. Important to this goal is the optimal utilization of resources, which requires a detailed understanding of the costs associated with curative therapy.

Treatment options for HCV infection have undergone a major transformation with the introduction of direct-acting antivirals (DAAs). These interferon-free regimens are highly effective and well tolerated, however the price of DAAs remains a barrier to treatment. This is where cost-effectiveness analysis can play a critical role in helping to elucidate how the investment of resources impacts long term outcomes.


photo: Jag Chhatwal, PhD

Jag Chhatwal, PhD

Senior Scientist, Massachusetts General Hospital and Assistant Prof., Harvard Medical School

photo: Rakesh Aggarwal, MD, DM

Rakesh Aggarwal, MD, DM

Professor of Gastroenterology at the Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

photo: Qiushi Chen, PhD

Qiushi Chen, PhD

Assistant Professor, College of Engineering, The Pennsylvania State University

photo: Emily Bethea, MD

Emily Bethea, MD

Fellow, Gastroenterology Unit at Massachusetts General Hospital.

photo: M. A. Ladd

M. A. Ladd, BS

Systems Manager, MGH Institute for Technology Assessment

photo: Yvan Hutin

Yvan Hutin, MD, PhD

Technical Officer, Strategic Information, WHO

photo: Peter Mueller

Peter P. Mueller, PhD

Postdoctoral Fellow, Harvard Medical School

photo: Yueran Zhuo

Yueran Zhuo, PhD

Postdoctoral Fellow, Harvard Medical School

About Hep C Calculator

Hep C Calculator is an interactive tool developed to evaluate the cost-effectiveness of DAAs for the treatment of HCV globally. The tool utilizes a mathematical model to simulate the life course of HCV-infected populations in 28 countries (considered as priority countries by the World Health Organization). The natural history of HCV calculated using this model has been validated with the results of a multicenter follow-up study of patients with advanced fibrosis.

An input panel (on the left side) of the Hep C Calculator allows users to select a country, local price of DAAs and laboratory tests, annual cost of management of various HCV disease stages (health states), and patient characteristics. For each set of selected values, the outcomes of two strategies – treatment with DAAs versus no treatment – are compared. The user can thus evaluate in real-time the following outcomes for each strategy: total costs (including the cost of HCV treatment and of downstream events such as the development of cirrhosis), quality-adjusted life-years (QALYs), and the cumulative incidences of decompensated cirrhosis, liver cancer, and HCV-related deaths. The model uses the health sector perspective, and calculates the incremental cost-effectiveness ratio (ICER) to determine whether treatment with DAAs produces cost-effective or cost-saving results. Read More...